Dehydrocholic acid
Dehydrocholic acid
CAS: 81-23-2
Molecular Formula: C24H34O5
Dehydrocholic acid - Names and Identifiers
| Name | Dehydrocholic acid |
| Synonyms | Acolen Bilidren Bilostat Atrocholin Dehydrocholic acid acidedehydrocholique Acide dehydrocholique (5beta)-3,7,12-trioxocholan-24-oate 7,12-trioxo-(5beta)-cholan-24-oicaci 7,12-trioxo-(5-beta)-cholan-24-oicaci 3,7,12-Trioxo-5beta-cholan-24-oic acid 3,7,12-trioxo-5-beta-cholan-24-oic acid dehydrocholic acid free acid*crystalline 3,7,12-Triketocholanic acid~3,7,12-Trioxo-5-beta-cholan-24-oic acid 4-[(5S,10S,13R,17R)-10,13-dimethyl-3,7,12-trioxo-1,2,4,5,6,8,9,11,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-17-yl]pentanoic acid |
| CAS | 81-23-2 |
| EINECS | 201-335-7 |
| InChI | InChI=1/C24H34O5/c1-13(4-7-21(28)29)16-5-6-17-22-18(12-20(27)24(16,17)3)23(2)9-8-15(25)10-14(23)11-19(22)26/h13-14,16-18,22H,4-12H2,1-3H3,(H,28,29)/p-1/t13-,14+,16-,17+,18+,22+,23+,24-/m1/s1 |
Dehydrocholic acid - Physico-chemical Properties
| Molecular Formula | C24H34O5 |
| Molar Mass | 402.53 |
| Density | 1.0687 (rough estimate) |
| Melting Point | 238-240 °C |
| Boling Point | 444.65°C (rough estimate) |
| Specific Rotation(α) | 29 º (c=2, dioxane) |
| Flash Point | 319.5°C |
| Water Solubility | 65mg/L(30 ºC) |
| Solubility | Slightly soluble in chloroform, slightly soluble in ethanol, and almost insoluble in water. |
| Vapor Presure | 0.013Pa at 20℃ |
| Appearance | White loose powder |
| Color | White to Off-White |
| Merck | 14,2868 |
| BRN | 3226734 |
| pKa | pKa 5.12(H2Ot = 20c > CMC) (Uncertain) |
| Storage Condition | Sealed in dry,Room Temperature |
| Refractive Index | 30.5 ° (C=2, Dioxane |
| MDL | MFCD00066410 |
| Physical and Chemical Properties | This product is extracted from animal bile bile bile acid by hydrogenation. White loose powder; Odorless, bitter taste. Mp 231-242 ℃, melting distance within 3 ℃. Dissolved in sodium hydroxide solution, slightly soluble in chloroform, slightly soluble in ethanol, almost insoluble in water. This product is beneficial to bile and promote bile secretion, it can stimulate liver cells to secrete a large number of low specific gravity, low viscosity of bile, promote bile drainage and is conducive to bile and gallbladder bacteria, inflammatory products, toxins, the discharge of gallbladder sand and small stones, plays a role in washing and cleaning the biliary system. |
Dehydrocholic acid - Risk and Safety
| Safety Description | 24/25 - Avoid contact with skin and eyes. |
| WGK Germany | 2 |
| RTECS | FZ2300000 |
| TSCA | Yes |
| HS Code | 2918300000 |
Dehydrocholic acid - Reference
| Reference Show more | 1. Song Lin, Tian-yang Wang, Hua-rong Xu, Xin-nong Zhang, Qi Wang, Ran Liu, Qing Li, Kai-shun Bi,A systemic combined nontargeted and targeted LC-MS based metabolomic strategy of plasma and liver on pathology exploration of alpha-naphthylisothiocyanate induce 2. [IF=3.935] Song Lin et al."A systemic combined nontargeted and targeted LC-MS based metabolomic strategy of plasma and liver on pathology exploration of alpha-naphthylisothiocyanate induced cholestatic liver injury in mice."J Pharmaceut Biomed. 2019 Jul;171:180 3. [IF=5.81] Zhao WW et al."Ilexsaponin A1 Ameliorates Diet-Induced Nonalcoholic Fatty Liver Disease by Regulating Bile Acid Metabolism in Mice.."Front Pharmacol. 2021 Dec;12:771976-771976 |
Dehydrocholic acid - Nature
Open Data Verified Data
This product is a white loose powder. Odorless and bitter. Slightly soluble in chloroform, slightly soluble in ethanol, almost insoluble in water; Dissolved in sodium hydroxide solution. The melting point is 231~242 deg C, the melting distance within 3 deg C. This product is a synthetic derivative of cholic acid, with choleretic, promote the role of bile secretion. Rapid onset, intravenous injection of 20~30min to achieve the maximum effect, the maintenance time is short. Mainly increases the water in the bile, the total amount of its discharge is significantly increased. But does not increase the secretion of solid components, so that bile dilution, play a role in cleaning the biliary tract. This is different from the role of natural bile salts, natural bile salts to the secretion of bile and its components are increased, and can promote the absorption of fat and fat soluble vitamins, and dehydrocholic acid to this effect is very weak. In addition, this product also promotes liver blood flow and bilirubin excretion and diuretic effect.
Last Update：2024-01-02 23:10:35
Dehydrocholic acid - Standard
Authoritative Data Verified Data
This product is 3, 7, 12-trioxo-5b-cholane-24-acid. Calculated as dried product, the content of C24H3405 shall not be less than 98.5%.
Last Update：2024-01-02 23:10:35
Dehydrocholic acid - Trait
Authoritative Data Verified Data
- This product is white loose powder; Odorless.
- This product is slightly soluble in chloroform, slightly soluble in ethanol, almost insoluble in water; Dissolved in sodium hydroxide solution.
specific rotation
take this product, precision weighing, and two oxygen six ring dissolved and quantitative dilution of each ml containing about 20mg of solution, according to the law (General 0621), the specific rotation is from ten 29.0 ° to ten 32.5 °.
Last Update：2022-01-01 11:34:02
Dehydrocholic acid - Use
Open Data Verified Data
- choleretic drug.
- usage and dosage: 0. 25~0.5g orally once, 0. 75~1. 5g per day.
Last Update：2022-01-01 11:14:01
Dehydrocholic acid - Differential diagnosis
Authoritative Data Verified Data
- take about 5mg of this product, add 1 drop of sulfuric acid and formaldehyde, dissolve it, place it for 5 minutes, and add 5ml of water. The solution is yellow and has Cyan fluorescence.
- take about 20mg of this product, add 1 ml of ethanol, shake, mix well, add M-dinitrobenzene solution (take 1g of M-dinitrobenzene, add 100ml of ethanol to dissolve, it is obtained). 5 drops of this solution (freshly prepared) and 0.5 of sodium hydroxide solution (1- 8) were placed, and the solution was purple or purple-red, gradually turning brown.
- The infrared absorption spectrum of this product should be consistent with that of the control (Spectrum set 715).
Last Update：2022-01-01 11:34:02
Dehydrocholic acid - Safety
Open Data Verified Data
-
li has laxative effect, dry mouth, skin itching, etc. For a long time to reduce the amount of bile secretion, "liver fatigue" phenomenon, can be used to prevent and treat glucocorticoid or ATP. Complete obstruction of the biliary tract and severe hepatitis patients disabled.
- light-shielding storage, closed storage.
Last Update：2022-01-01 11:14:01
Dehydrocholic acid - Exam
Authoritative Data Verified Data
odor
take 2.0g of this product, add 100ml of water, boil for 2 minutes, should be odorless.
clarity and color of ethanol solution
take this product 0.10g, add ethanol 30ml, shake to dissolve, the solution should be clear and colorless.
chloride
take this product l. Add 100ml of water, shake for 5 minutes, filter, take and continue the filtrate 0801, check according to law (General rule 0.02%), compared with the control solution made of standard sodium chloride solution, not more concentrated ().
sulfate
Take 10ml of the filtrate remaining under the above chloride check item and check it according to law (General rule 0802). Compared with the control solution made of 0.05% of standard potassium sulfate solution, it should not be more concentrated ().
barium salt
take 2.0g of this product, add 100ml of water and 2ml of hydrochloric acid, boil for 2 minutes, cool, filter, and wash with water. Combine the wash with the filtrate to make 100ml, shake well; take 10ml plus 1ml of dilute sulfuric acid, the solution should not be turbid.
loss on drying
take this product, dry to constant weight at 105°C, weight loss shall not exceed 1.0% (General rule 0831).
ignition residue
take l.Og of this product and check it according to law (General rule 0841). The residue left shall not exceed 0.3%.
Heavy metals
The residue left under the item of taking the ignition residue shall not contain more than 20 parts per million of heavy metal when examined by law (General rule 0821, Law II).
microbial limit
check by microbial limit of non-sterile products •. The microbial count method (General rule 1105) and the control bacteria inspection method (General rule 1106) and the microbial limit standard for non-sterile drugs (General rule 1107) shall comply with the regulations, at the same time, 10g of the test article shall not be detected salmonella.
Last Update：2022-01-01 11:34:03
Dehydrocholic acid - Content determination
Authoritative Data Verified Data
take about 0.5g of this product, weigh it accurately, Add 60ml of neutral ethanol (neutral to phenolphthalein indicated solution), heat it on a boiling water bath to dissolve and cool it, add phenolphthalein indicator liquid drops with the new boiling water 20ml, with sodium hydroxide titration solution (0.1 mol/L) titration, adding 100ml of fresh boiling cold water to the near end point to continue titration to the end point. Equivalent to 40.25mg of C24H34O5 per 1 ml of sodium hydroxide titration solution (O.lmol/L).
Last Update：2022-01-01 11:34:04
Dehydrocholic acid - Category
Authoritative Data Verified Data
choleretic drugs.
Last Update：2022-01-01 11:34:04
Dehydrocholic acid - Storage
Authoritative Data Verified Data
light shielding, sealed storage.
Last Update：2022-01-01 11:34:04
Dehydrocholic acid - Dehydrocholic acid tablets
Authoritative Data Verified Data
This product contains dehydrocholic acid (C24H3405) should be labeled the amount of 93.0% ~ 107.0%.
trait
This product is white tablet.
identification
take 1 tablet of this product, grind it, put it in a test tube, add 10ml of sodium carbonate test solution, dissolve dehydrocholic acid, add several drops of nitrogen benzene sulfonic acid test solution, and gradually appear red.
examination
should be in accordance with the relevant provisions under The tablet item (General rule 0101).
Content determination
Take 20 tablets of this product, precision weighing, fine grinding, precision weighing appropriate amount (about 0.5g equivalent to dehydrocholic acid), plus neutral ethanol (phenolphthalein indicates neutral) 40ml and 20ml of water, heated on a water bath for 10 minutes, and then shaken to dissolve dehydrocholic acid, add 3 drops of phenolphthalein indicator solution, and use sodium hydroxide titration solution (0.lmol/L) titration, to the end point, add 100ml of New boiling cold water to continue titration, that is, every 1 ml of sodium hydroxide titration solution (O. 1 mol/L) equivalent to 40.25mg of C24H34O5.
category
with dehydrocholic acid.
specification
0.25g
storage
light shielding, sealed storage.
Last Update：2022-01-01 11:34:05
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